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murR [2018-07-26 16:44:04]
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murR [2018-07-26 16:44:04]

probably transcriptional regulator of genes required for the utilization of N-acetylmuramic acid, homolog to E. coli MurR
locus
BSU01690
pI
6.87
mw
30.56 kDa
protein length
283 aa Sequence Blast
gene length
849 bp Sequence Blast
function
probably regulation of muramic acid utilization
product
transcriptional repressor
essential
no
synonyms
ybbH
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • Gene

    Coordinates
    191,183 → 192,034

    The protein

    Structure

  • [PDB|2O3F] (N-terminal domain)

    • Expression and Regulation

    Operons

    genes
    [gene|0B1F43F43A4DC1574A153DBFBAA5D0A1855F9B61|murQ]-[gene|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]-[gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]-[gene|DEACFD435DB01C4B3ADEF397BEE08E2E7C7FCC36|amiE]-[gene|A5D4BF262BD365DCEBA9358C8DB295E605DE4D84|nagZ]-[gene|005D37F34CA3D6891F7D8FF7A2AFA1CBCB556FFE|ybbC]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|125872506C400CB6B3DAEA8B5130B064DFBA4494|MurR]: repression, [pubmed|30038046], in [regulon|125872506C400CB6B3DAEA8B5130B064DFBA4494|MurR regulon]

    • regulation

  • expressed in late exponential and early stationary phase [Pubmed|20400549]
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    Biological materials

    Mutant

  • MGNA-B951 (ybbH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1950 NBRP B. subtilis, Japan]
  • BKE01690 (Δ[gene|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGTGGCCATTCTAGTTCTCT, downstream forward: _UP4_TAAGGCATCTTGAAGGGGAG
  • BKK01690 (Δ[gene|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGTGGCCATTCTAGTTCTCT, downstream forward: _UP4_TAAGGCATCTTGAAGGGGAG

    • References

  • 15060041,20400549,10627040,22383849